ABSTRACT
RESUMEN Introducción: El Síndrome Coronario Agudo es considerado una complicación de la ateroesclerosis con alta morbilidad y mortalidad en ambos sexos. Tiene un importante impacto socioeconómico evidenciado en los años de vida potencial perdidos. Objetivo: Caracterizar por clínica y angiografía a mujeres y hombres diagnosticados con Síndrome Coronario Agudo. Material y Métodos: Se realizó un estudio descriptivo de diseño transversal con 214 pacientes, del Servicio de Cardiología del Hospital Universitario "Manuel Ascunce Doménech" de Camagüey, desde enero de 2015 hasta enero de 2017. La fuente primaria estuvo dada por el informe escrito de los resultados de la coronariografía realizada en el Cardiocentro "Ernesto Che Guevara" de Villa Clara y las historias clínicas hospitalarias de cada paciente; se llenó un formulario con las siguientes variables: grupos de edades, sexo, factores de riesgo, forma clínica de presentación, resultado coronariográfico y conducta médica. Este documento se computarizó, se aplicaron pruebas de significación estadística y los resultados se ilustraron en tablas. Resultados: Predominaron los hombres, edad mayor de 60 años, la hipertensión arterial fue el factor de riesgo coronario de mayor representatividad para ambos sexos y se afectó de manera significativa la arteria descendente anterior. Conclusiones: A medida que avanza la edad las mujeres tienen igual o más riesgo que los hombres de sufrir enfermedad arterial coronaria, pues en ambos se incrementa la exposición a los predictores de riesgo. Las diferencias en las formas de expresión clínica, angiográfica y percepción de la enfermedad, determinan las estrategias de intervención y conducta médica.
ABSTRACT Introduction: Acute Coronary Syndrome is a complication of atherosclerosis with high morbidity and mortality in both sexes. It has an important socioeconomic impact which is evidenced in the years of potential life lost. Objective: To characterize women and men diagnosed with acute coronary syndrome by performing angiography in the clinical practice. Material and Methods: A descriptive cross-sectional study was carried out with 214 patients from the Cardiology Service of Manuel Ascunce Domenech University Hospital in Camagüey from January 2015 to January 2017. The primary source was the written report of the results of the coronary angiography performed at Ernesto Che Guevara Health Center in Villa Clara and the clinical record of each patient. A database was developed for the following variables: age groups, sex, risk factors, clinical presentation, result of coronary angiography and medical behavior. This document was computerized; tests of statistical significance were applied and the results were illustrated in four tables. Results: Men and age over 60 years predominated in the study; arterial hypertension was the most representative coronary risk factor in both sexes and the anterior descending artery was significantly affected. Conclusions: With advancing age, women are at the same or greater risk of presenting coronary artery disease than men. In both genders, the risk factors increase. The differences in the clinical an angiographic features of the disease determine the medical behavior.
ABSTRACT
Objective To observe the clinical effect of acute angina pectoris in cardiovascular surgery. Methods 92 patients with acute angina were enrolled in our hospital from March 20 to March 2017 were randomly divided into study group and control group,with 46 cases in each group. The control group was treated with enalapril and aspirin enteric-coated tablets. The study group was treated with clopidogrel on the basis of the control group.The clinical effect of the two groups after treatment was observed, and the incidence, duration and total effective rate of acute angina were compared between the two groups. Results The incidence of acute angina pectoris and pain time in the study group were significantly lower than in the control group (P<0.05). The total effective rate of the treatment group was significantly higher than that of the control group (P<0.05). Conclusion The combination of enalapril, aspirin enteric-coated tablets and clopidogrel in patients with acute angina pectoris can effectively reduce the number of acute angina pectoris and shorten the duration of onset of pain. The clinical effect is significant and high clinical application value.
ABSTRACT
Objective To observe the clinical effect of acute angina pectoris in cardiovascular surgery. Methods 92 patients with acute angina were enrolled in our hospital from March 20 to March 2017 were randomly divided into study group and control group,with 46 cases in each group. The control group was treated with enalapril and aspirin enteric-coated tablets. The study group was treated with clopidogrel on the basis of the control group.The clinical effect of the two groups after treatment was observed, and the incidence, duration and total effective rate of acute angina were compared between the two groups. Results The incidence of acute angina pectoris and pain time in the study group were significantly lower than in the control group (P<0.05). The total effective rate of the treatment group was significantly higher than that of the control group (P<0.05). Conclusion The combination of enalapril, aspirin enteric-coated tablets and clopidogrel in patients with acute angina pectoris can effectively reduce the number of acute angina pectoris and shorten the duration of onset of pain. The clinical effect is significant and high clinical application value.
ABSTRACT
Increased production of free radicals under oxidative stress conditions plays a vital role in the impairment of endothelial function and also in the pathogenesis of ischemic heart diseases. Ischemia, followed by reperfusion, leads to the exacerbated formation of oxy- free radicals. These reactive oxygen species through a chain of reactions damage the cardiomyocytes and cause more injury to the myocardium. L-Arginine is reported to act as free radical scavenger, inhibits the activity of pro-oxidant enzymes and thus acts as an antioxidant and these roles of L-arginine are mediated by nitric oxide (NO). In the present study, the effect of oral administration of L-arginine (3 g/day for 7 days) on some antioxidant enzymes, total thiols, lipid peroxidation measured as malondialdehyde (MDA), and plasma ascorbate levels in myocardial ischemic patients was investigated. We observed an increase in the activity of superoxide dismutase (SOD), total thiols (T-SH) and plasma ascorbate levels and a decrease in the activity of xanthine oxidase (XO), MDA levels, carbonyl content and serum cholesterol in the patients on oral administration of L-arginine. The present study demonstrates that L-arginine administration may be beneficial to patients with myocardial ischemic disorders, such as acute myocardial infarction and acute angina.